I would say so. It might take some tweaking, but in the root folder of plogger, the file named gallery.php has a variable "$output". This contains all the markup for html. Make sure you are not editing the PHP code that is inline with the markup. Combining the tweaks to this layout and editing the CSS file, you should be able to make it look like you want.
Anyone, please correct me if I'm wrong... I've only been working with Plogger for 3 days.
I'm sorry, the above comment was to edit the gallery view, not the admin.
To edit the admin, you will need to look in plog-globals.php to edit the header and if you really want to edit the layout of each admin page you will have to edit that specific $output string for that specific page.
Example: To edit the layout of the Manage page, open plog-manage.php in plogger/admin. look for $output. This value is strung all through the file and might be very hard to decipher if you do not know what you are looking at.
To just edit the colors to match your color scheme, stick to the CSS file located in plogger/css/admin.css